Bio-Enhanced 20 offers enhanced bioavailability as a self-emulsifying drug delivery system
Davos Life Science is pleased to announce the launch of its newly developed product: Naturale3 Bio-Enhanced 20, the epitome of the SEDDS (self-emulsifying drug delivery system) formula that gives at least two times higher bioavailability than the competition.
Upon ingestion, Naturale3 Bio-Enhanced 20 forms a micro/nano emulsion in the gut that enables high absorption into the body and reduces breakdown in the liver, independent of dietary fat or food intake. Davos R&D validated that Naturale3 Bio-Enhanced 20 delivers tocotrienol at consistently much higher levels than current commercially available product.
Vitamin E is widely recognised as an important lipid-based antioxidant that mainly protects unsaturated fatty acids on cell membranes. Although α-tocopherol is recognised as the isoform with the highest vitamin E activity, tocotrienol has been shown to have much higher free radical scavenging ability than α-tocopherol within the cell.
This is due to the higher penetration of tocotrienol molecules into the cell while α-tocopherol mainly resides on the plasma membrane based on Davos in-house research. As such tocotrienol is able to protect important organelles like the mitochondria (responsible for energy production) and DNA (genetic code) from oxidative stress induced damage better than α-tocopherol.
Increasingly, recent studies show that tocotrienol — but not α-tocopherol — shows better clinical benefits in cardiovascular, brain, liver and women’s health. Numerous studies indicate that cholesterol and triglyceride levels can be controlled with prolonged consumption of palm-derived tocotrienol with the effect mainly due to gamma & delta tocotrienol.
These two tocotrienol isomers are also responsible for controlling inflammatory responses in the body especially in conditions such as metabolic syndrome, prediabetes, obesity, fatty liver etc. Alpha tocotrienol, which is abundant in palm, had been extensively researched for brain health benefits including reduction of post-stroke injury and recovery.
A recent study also found that patients with mild cognitive impairment and Alzheimer’s disease have low levels of vitamin E in their blood plasma, in particular alpha and gamma tocotrienol. Although vitamin E in general has been well studied for its absorption and metabolic fate, the plasma concentration of tocotrienol was found to be much lower compared to tocopherols.
Absorption of tocotrienol in humans is enhanced in the presence of a high fat diet but there is large variability in absorption efficiency between individuals. Davos proprietary formulation — Bio-Enhanced 20 — overcomes this problem by consistently delivering tocotrienol at high amount in the plasma. Naturale3 Bio-Enhanced 20 will be the preferred formula for brand owners and manufacturers as it enables the full benefits of tocotrienol to be achieved for all health concerns via its optimised delivery system.