Depending on the dosage form, CBD take in doesn’t have to be complicated

4-Aug-2021

Here the experts at Biogrund discuss the benefits of adding CBD, natural high-sources of vitamins, probiotics, omega 3-6-9 fatty acids, antioxidants to natural supplements

What is CBD?

CBD stands for cannabidiol. It is the second most prevalent of the active ingredients of cannabis (marijuana) and one of the 113 cannabinoids found in the hemp plant. Full-spectrum hemp products include all of these, including trace amounts of THC. To get CBD without THC it needs to be isolate. Isolating the CBD strips away all of the other compounds.

Clinical research studies on the effects of CBD have been collected for several years. However, there are currently no sufficient, high-quality results on whether CBD is effective for conditions such as anxiety, cognition, movement disorders and pain.

What is the industry looking for?

Simplify the intake, handling and precision dosing
Taste and odour masking
Further dosage forms. Drops are already available en mass on the market, capsules and tablets can extend the portfolio
Production cost savings. Liquid filled capsules are expensive
So to transfer the oil into powder to make it suitable for tablets and capsules might be a good option
Optimise bioavailability
Clean label products in the nutraceutical and food industry.

Adding CBD, natural high-sources of vitamins, probiotics, omega 3-6-9 fatty acids, antioxidants, to natural supplements

Industries are looking to add natural high-sources of vitamins, probiotics, omega 3-6-9 fatty acids, antioxidants, amino acids and hemp to their natural supplements products. Often in form of an oil or oily powder. Talking about the latter, manufacturers can achieve some benefits when using microencapsulation for oil powders. Especially if the oil powder is then filled into hard gelatin or hypromellose capsules, precision dosing of exact amounts of ingredients or nutrients can be achieved. Flavour and odour masking can be minimise unpleasant tastes and smells associated with certain nutrients. Protection from moisture, acids, heat and oxygen. It enhances stability, bioavailability and delivery. As well as ease of handling due to dry and free flowing.

To incorporate oily substances in powder with purely natural ingredients and to encapsulate the product or press a tablet can thus be a done in simple way. And it could also open up the possibility of combining CBD with other active ingredients. Therefore, natural ingredient powder premixes like CompactCel MAB can support absorbing oily substances like hemp in a ratio up to 1:8. Beside the high absorption of oil it is developed to keep flowability and powder form.

Example:

20 mg of hemp shall be filled in a size 0 capsule. Therefore, approx. 30 mg oil (containing 20mg CBD) needs to be incorporate in 500 mg powder. As a result, 6% of oil must be in the capsule. Using CompactCel MAB for the oil absorption process makes it possible to bind up to 12.5 % oil in powder. And even after that, it still has good flow properties. Hard capsules can thus be filled easily without the powder mass clumping together.

Note: Regarding the exact legal status of CBD please inform yourself about federal government laws of your country.

References:

1-3 en.wikipedia.org/wiki/Cannabidiol
Campos AC, Moreira FA, Gomes FV, Del Bel EA, Guimarães FS (December 2012). “Multiple mechanisms involved in the large-spectrum therapeutic potential of cannabidiol in psychiatric disorders”. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences (Review). 367 (1607): 3364–78. doi:10.1098/rstb.2011.0389. PMC 3481531. PMID 23108553.
Black N, Stockings E, Campbell G, Tran LT, Zagic D, Hall WD, et al. (December 2019). “Cannabinoids for the treatment of mental disorders and symptoms of mental disorders: a systematic review and meta-analysis”. The Lancet. Psychiatry. 6 (12): 995–1010. doi:10.1016/S2215-0366(19)30401-8. PMC 6949116. PMID 31672337.
VanDolah HJ, Bauer BA, Mauck KF (September 2019). “Clinicians’ Guide to Cannabidiol and Hemp Oils”. Mayo Clinic Proceedings. 94 (9): 1840–1851. doi:10.1016/j.mayocp.2019.01.003. PMID 31447137.
www.health.harvard.edu/blog/cannabidiol-cbd-what-we-know-and-what-we-dont-2018082414476