Cerebelle combines a proprietary blend of extracts made from two potent polyphenol-rich fruits, grape and wild blueberry
DianaFood, specialists in nutritional solutions made from natural ingredients and nutrition division of German-based Symrise, will launch Cerebelle, a proprietary blend of extracts made from two potent polyphenol-rich fruits, grape and wild blueberry, clinically proven to prevent age-related cognitive decline in healthy older adults at SupplySide West.
The bioavailability of the two components was studied with consistent results showing the combination of the ingredients increased specific flavonoid bioavailability, showing the unique efficacy of Cerebelle.
Grape and wild blueberry extracts contribute specific polyphenols with neuroprotective properties. Cerebelle compliments a broad variety of consumer products ranging from traditional dietary supplements to functional foods and beverages.
A clinical study recently published in the Journals of Gerontology by researchers from Canadian-based Institute of Nutrition and Functional Foods (INAF) and the University of Bordeaux in France, showed that a 6 month supplementation with Cerebelle improved memory in healthy older adults.
In a bicentric, double-blind, randomised, placebo-controlled study, 215 healthy subjects from 60–70 years of age received for 24 weeks either a placebo or 600 mg/d of Cerebelle.
Subjects in both groups performed a series of cognitive tests, designed by CANTAB to assess visuospatial learning, and episodic memory (Paired Associate Learning, PAL), verbal recognition memory (VRM) and working memory (SSP). Supplementation with Cerebelle improved VRM free recall across the entire group.
According to Joyce Cascella, DianaFood, consumer health category manager, it was further noted that within the subgroup with advanced cognitive decline at baseline, 6 month supplementation with Cerebelle showed improvement of both PAL and VRM. These results infer that Cerebelle improves verbal memory in healthy elderly people. The study also demonstrated that Cerebelle improves episodic memory, or the ability to recall previous events, emotions and places, in healthy senior people with a lower level of memory performance.
“Preclinical data have shown that polyphenols from Cerebelle can decrease the production of pro-inflammatory compounds in the brain,” said Cascella.
"The published preclinical study demonstrated that these polyphenols stimulate the production of nerve growth factor in the brain with an increase in synaptic plasticity, leading to an improvement of memory. These three different pathways strengthen our understanding of the capability of Cerebelle to protect against the memory decline associated with aging.”
DianaFood provides natural health solutions that are supported by robust science as it envisions a growing need for innovative solutions combining actives for a synergistic action for human health, such as combining probiotics with botanical extracts.
DianaFood offers well-being solutions for the food and consumer health industry and is committed to empowering health-conscious people to be active participants of their own wellness by delivering innovative, natural ingredient solutions that provide health, pleasure and trust. By utilising these principles for the past 25 years, DianaFood has become the natural provider of high value, clean label ingredients and standardized nutritional actives.
With its advanced team of agronomists, DianaFood can select the best sources of fruit and vegetables, harvested at the perfect time when their nutritional composition is optimal. This unique sourcing combined with its know-how in extraction processes and ability to work with leading scientists, enables the company to develop ground-breaking ingredient products.