Tocotrienol-tocopherol complex more potent than a single tocotrienol isoform
Single, pure tocotrienol isoforms are not as effective as the natural full-spectrum palm tocotrienol-tocopherol complex, EVNol (previously known as Tocomin), in reducing oxidative stress and restoring endothelium-dependent relaxation reports a newly published study from the Royal Melbourne Institute of Technology University (RMIT), Australia.
The study also highlights that the presence of alpha-tocopherol is essential for tocotrienols to exert this vascular health benefit.
Abnormal endothelial cell function (endothelial dysfunction) is a sign of various vascular diseases and, importantly, an early marker in the development of atherosclerosis and disease-induced oxidative stress. This study set out to compare the antioxidant activity of individual tocotrienol isoforms (alpha, gamma, and delta), alpha-tocopherol and Tocomin (now known as EVNol).
EVNol is a natural full-spectrum tocotrienol-tocopherol complex derived from red palm oil, consisting of approximately 78% tocotrienols and 22% alpha-tocopherol. In addition, the study investigated the potency of these various vitamin E groups in preserving endothelial function during oxidative stress.
The researchers found that the individual tocotrienol forms (alpha, gamma, delta) effectively scavenged superoxide, but did not improve endothelial function unless alpha-tocopherol was present. Alpha-tocopherol and alpha, gamma and delta tocotrienols were able to reduce oxidative stress at concentrations as low as 10-3mg/mL, whereas EVNol was able to achieve the same effect at much lower concentrations (as low as 10-5mg/mL).
‘This is an exciting study that provides new evidence to show that alpha-tocopherol plays an important role in preserving endothelial function. The natural complex of tocotrienols and alpha-tocopherol in EVNol functions synergistically to prevent oxidative stress and restore endothelial function at a very low concentration. It’s approximately 100 times more potent than alpha-tocopherol alone,’ says Mr W.H. Leong, CEO of ExcelVite Inc.
‘There are eight isoforms of vitamin E in nature. Nature knows best that for vascular protection, both tocotrienols and tocopherols work together synergistically to confer a higher beneficial effect. This also reflects recent European research studies that show high blood levels of all vitamin E forms (mixed tocopherols and mixed tocotrienols) protect elderly people from the risk of mild cognitive impairment and Alzheimer’s disease,’ added Mr Leong.