Two new studies have recently been published on the topical benefits of Sabinsa’s pTeroWhite natural pterostilbene isolated and purified from Pterocarpus marsupium heartwood and formulated as a cream
The studies further the body of science into pTeroWhite’s value as a cosmeceutical ingredient for antiageing, skin brightening and as a natural SPF agent.
"An Open-Label Single-Arm, Monocentric Study Assessing the Efficacy and Safety of Natural Pterostilbene (Pterocarpus Marsupium) for Skin Brightening and Antiaging Effects," published in Clinical, Cosmetic and Investigational Dermatology, was conducted as an open-label, single-arm, monocentric efficacy investigation in 38 healthy volunteers who applied a cream containing 0.4% pterostilbene for 8 weeks.
The dermatological assessment, together with instrumental and image analysis, suggests that pterostilbene effectively improves skin brightness, elasticity, reduces the appearance of fine lines, wrinkles, and improves skin texture as compared with baseline in the subjects studied.
The researchers observed a positive change at all time points in skin hydration and elasticity in both male and female subjects with regular usage of the pTeroWhite cream.
They found significant improvement in under-eye fine lines at all-time points and in wrinkles, frown lines, and crow’s feet area at the end of the study. The pterostilbene preparation was able to improve the skin luminosity with continuous application.
All the subjects agreed that the test product made their skin appear moisturized, brighter, younger, firmer, and even toned.
Further, researchers observed no product-related skin irritation, intolerance, or adverse events during the study. The report concluded that the application of pterostilbene cream twice daily for 8 weeks was safe and improved skin texture and tone.
A second clinical study, "A Randomized Study to Determine the Sun Protection Factor of Natural Pterostilbene from Pterocarpus marsupium," published in the journal Cosmetics, demonstrated the effect of pTeroWhite as a natural SPF ingredient.
A cream formulation, containing 0.4% of pTeroWhite, was evaluated in 12 healthy volunteers as per the ISO 24444:2010 regulations and showed an in vivo SPF value of 6.2 ±1.30. The cream was found to be safe and non-irritant in a repeated patch test conducted in 25 healthy individuals before the SPF study.
The cream showed an SPF of 8.84 ±0.01 in vitro, while pTeroWhite as an ingredient had an SPF value of 21.73 ±0.06. Further, the study demonstrated the potent antioxidant effects of pTeroWhite in various in vitro and cellular test systems. The study concluded that pTeroWhite could be a safe ingredient in topical sun-protective formulations.
“We’ve long thought that natural pterostilbene had tremendous potential in cosmeceutical applications, which is why we began conducting research, ” said Sabinsa founder and chairman Dr Muhammed Majeed. “Investigations are continuing to further expand our knowledge to support new product applications.”