Meta-analyses highlights the potential risk of MTHFR polymorphism in folate metabolism
Methyltetrahydrofolate reductase is one of the most important enzymes in human physiology and its deficiencies in production or function have been associated with increased risk in pregnancy and other human diseases.
Methyltetrahydrofolate reductase (MTHFR) polymorphism is one of the main areas of current research.
In the recent months, several publications have investigated the potential effects of the MTHFR enzyme polymorphism on folate metabolism and its association with increased risk of congenital malformations, degenerative diseases and decreasing health and wellbeing in old age.
Population with the MTHFR gene variation partially metabolises folic acid and food folates to the active form of 5-MTHF, so the individual is not able to maintain an adequate folate status during all life stages.
Two different meta-analysis correlated the polymorphism with the risk of male infertility
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