Quatrefolic and male infertility


Meta-analyses highlights the potential risk of MTHFR polymorphism in folate metabolism

Methyltetrahydrofolate reductase is one of the most important enzymes in human physiology and its deficiencies in production or function have been associated with increased risk in pregnancy and other human diseases.

Methyltetrahydrofolate reductase (MTHFR) polymorphism is one of the main areas of current research.

In the recent months, several publications have investigated the potential effects of the MTHFR enzyme polymorphism on folate metabolism and its association with increased risk of congenital malformations, degenerative diseases and decreasing health and wellbeing in old age.

Population with the MTHFR gene variation partially metabolises folic acid and food folates to the active form of 5-MTHF, so the individual is not able to maintain an adequate folate status during all life stages.

Two different meta-analysis correlated the polymorphism with the risk of male infertility

  • Hong et al., took in consideration a total of 15 studies with 3853 patients with infertility and 3613 healthy controls — results showed that T variant of MTHFR C677T gene polymorphism was significantly associated with an increased risk of male infertility1
  • Zhang et al., included a total of 20 studies with 4293 cases and 4507 controls found that the A variant of MTHFR A1298C may be a potential risk factor for male infertility, especially in the Asian population.2

Quatrefolic completely bypasses the damaged MTHFR conversion step and delivers a finished folate that can be immediately use by the body without any kind of metabolisation, reducing the risk of degenerative diseases and increasing health and wellbeing.

For more information visit www.quatrefolic.com


  1. Hong et al., “Associations of C677T polymorphism in methylenetetrahydrofolate reductase (MTHFR) gene with male infertility risk: A meta-analysis,” Eur. J. Obstet. Gynecol. Reprod. Biol., 2017.
  2. Zhang et al., “Association between MTHFR A1298C polymorphism and male infertility: A meta-analysis,” J. Huazhong Univ. Sci. Technolog. Med. Sci., 2017.
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