First evidence of Lp(a) reduction
A pivotal study that further consolidates the ameliorating role that Sabinsa’s C3 Complex/BioPerine combination plays in the context of diabetes has just been published in Complementary Therapies in Medicine.
The study demonstrated the protective role that the C3 Complex/BioPerine combo plays in maintaining HDL functionality, reducing non-HDL-C and, for the first time in curcumin research, improvements in Lipoprotein(a), a structural component of LDL.
The results of a 12-week randomised double-blind placebo-controlled trial on subjects with type 2 diabetes showed promising outcome of using a combination of Sabinsa’s proprietary branded ingredients Curcumin C3 Complex (1000mg/day) and BioPerine (10 mg/day).
Fifty subjects in the active group and an equivalent number in the placebo group successfully completed the trial.
The analysis of the results showed that the Curcumin C3 Complex/BioPerine combination reduced the atherogenic lipid indices including non-HDL-cholesterol and Lp(a) while showing an increase in HDL-levels and improving HDL-functionality.
Although the importance of lowering non-HDL-cholesterol fraction has long been recognised, nutritional intervention to reduce Lp(a), a protective armour of the bad cholesterol LDL, has never been demonstrated in a clinical trial for curcuminoids.
The absence of effective drug therapy to reduce Lp(a), especially in diabetic patients who are more prone to cardiac events, further accentuates the importance of C3 Complex/BioPerine combo in such a scenario.
The only drug intervention to reduce Lp(a) is the recently introduced PCSK9 inhibitors that are extremely expensive and available only as an injectable. Lp(a) has been recognised as an independent risk factor for atherosclerosis, hence a nutritional intervention to reduce Lp(a) is immensely welcome.
“The overall conclusions in this study together with earlier studies on C3 Complex/BioPerine combination add to the body of science on its positive role in the health maintenance of diabetic subjects,” said Sabinsa founder Dr Muhammed Majeed, who contributed to the published study.