Akay Bioactives, a global leader in scientifically backed botanical ingredients, announces new clinical findings published in Frontiers in Pharmacology highlighting the benefits of its CurQfen® and FenuMat® Boswellia combination. The study demonstrates support for physical comfort, joint health, and overall function through a convenient once-daily dose.
This combination features CurQfen, a highly bioavailable curcumin complex, and Boswellia serrata, both delivered in Akay’s proprietary FenuMat matrix. This self-emulsifying hydrogel technology enhances bioavailability while supporting clean-label formulation.
Clinical study: Fast-acting support for physical wellness and comfort
A randomized, double-blind, placebo-controlled, three-arm, three-sequence comparative study (105 participants over 28 days) demonstrated that a combination of CurQfen + FenuMat Boswellia significantly supported improvements in pain, stiffness, neck disability scores, physical function, and overall quality of life. The once-daily dosage of just 400 mg delivered measurable results in routine activities such as working, reading, and driving.
Key outcomes:
-
Noticeable relief was observed within two weeks of use.
-
Intergroup comparisons revealed sustained improvements through the end of the study:
Physical function and wellness (BASDAI scores):
-
A 25.5% greater reduction by day 14 and a 65.5% reduction by day 28 in the CurQfen + FenuMat Boswellia group compared to placebo.
Neck, hip, and back pain:
-
Reduced by 21.7% at day 14 and by 76.1% at day 28.
General pain/swelling (other parts or joints):
-
Reduced by 27% at day 14 and 66.5% by day 28.
Morning stiffness:
-
Reduced by 45.7% at day 14, with continued improvement through the study period (-70%).
Quality of life improvements
Pain intensity during common daily tasks was also assessed through the validated Neck Disability Index (NDI):
-
After just two weeks, NDI scores dropped by approximately 29%.
-
By the end of the four-week intervention, the NDI score reduced by 51%, indicating meaningful gains in pain relief, mobility, and functionality.
Task-specific improvements:
-
Working difficulty: Reduced by 26% at day 14 and by 45% at day 28.
-
Driving difficulty: Reduced by 22% at day 14 and by 51% at day 28.
-
Reading difficulty: Reduced by 15% at day 14 and by 53% by the end of the study.
Inflammation modulation
The study also explored how the combination influenced key inflammatory markers:
NLRP3 (NOD-, LRR-, and pyrin domain-containing protein 3) is part of the NLRP3 inflammasome complex in the innate immune system. It detects cellular stress and triggers inflammation by activating caspase-1, which promotes the release of pro-inflammatory cytokines such as IL-1β and IL-18.
Results showed the following percentage change from baseline:
-
NLRP3 levels decreased by 39.3%.
-
IL-1β levels decreased by 59.3%.
These findings further support the role of CurQfen combined with FenuMat Boswellia in promoting physical well-being through inflammation modulation.
Safe, well-tolerated, and effective
The intervention was well-tolerated. Outcomes for liver or kidney function markers were well within normal range. No major side effects or adverse events occurred, reinforcing the safety and daily-use potential of this formulation.
Expert insights and future potential
“These findings mark a significant advancement in physical wellness research,” said Dr. Krishnakumar I.M., Chief Research Officer at Akay Bioactives. “The combination of CurQfen with FenuMat Boswellia not only supports physical comfort but also helps improve quality of life for routine activities like working, driving, and reading. It reflects our continued focus on delivering science-backed, natural health solutions.”
CurQfen combined with FenuMat Boswellia represents a plant-based, clinically substantiated solution that supports physical comfort, mobility, and everyday functionality. By targeting multiple inflammatory pathways, this formulation offers a comprehensive approach to whole-body wellness.
Akay Bioactives remains committed to pioneering innovations in bioactive ingredients, helping consumers around the world achieve better health through nature and science.