Catalent launches delayed release softgel technology

Published: 20-Oct-2020

The company says OptiGel DR offers several advantages including more efficient active ingredient absorption

Catalent has announced the launch of OptiGel DR technology for the formulation and manufacture of delayed/enteric release softgels. The technology allows softgel capsules to be formed by combining pectin, a naturally derived polysaccharide, with gelatin, eliminating the need for a separate capsule coating step.

The company says a delayed release profile protects active ingredients that may be degraded by acid in the stomach, releasing them directly in the intestines where they are absorbed, potentially enhancing bioavailability.

The capsules can also help reduce gastric reflux effects, often associated with pungent ingredients such as fish or garlic oils. The technology has the potential to encapsulate a range of ingredients.

“Catalent has a long history in softgel innovation, stretching back more than 85 years, and this latest evolution of the technology allows innovators to design the most efficient products, and bring superior pharmaceutical and nutraceutical products to the marketplace,” commented Dr Aris Gennadios, President, Softgel and Oral Technologies, Catalent.

“The technology we have developed allows the delayed release profile to be incorporated into the softgel capsule shell, broadening the applications, and making a separate capsule coating step unnecessary. This reduces time and yield loss and eliminates potential quality issues associated with coated softgels.”

Catalent’s site in St. Petersburg, Florida, is the first to offer OptiGel DR technology, with the capability being expanded to its other softgel manufacturing facilities in Brazil, Canada, Germany, Italy and Japan in the future.

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