Curcumin’s cognitive health benefit validated in breakthrough research

Published: 10-Aug-2022

Declining cognitive health, like most degenerative diseases is driven by chronic, sub-clinical inflammation. Curcumin is recognised as one of the best anti-inflammatory agents, but its uses are limited by its properties

Register to download "The world's most bioavailable curcumin in a single dose" infographic now.

HydroCurc using the patented LipiSperse dispersion technology from Pharmako Biotechnologies overcomes those challenges. Recent research in England and Australia is demonstrating the cognitive health benefits of supplementation with HydroCurc.


Most degenerative diseases are driven by chronic, sub-clinical inflammation. Curcumin’s myriad of health benefits can be attributed to its anti-inflammatory and antioxidant properties, reducing oxidative stress and inflammation caused by lifestyle factors.

Unique, delivery system

HydroCurc utilises a patented delivery system, which not only enhances bioavailability1, but delivers an unbeatable high active ingredient load (90%). This is important from an economic and ecological perspective. A Mechanistic Study demonstrates that LipiSperse protects the curcumin from degradation by acid during transit through the gastro-intestinal tract.2

Clinical research

A government co-funded study at UWS demonstrating HydroCurc not only being absorbed into blood but crossing the blood / brain barrier is a ground-breaking result.3 The in vitro study showed that HydroCurc is 6x more stable, had 5x higher recovery rate and a 10x higher transport rate compared to normal curcumin. In vivo application of HydroCurc significantly reduced the marker of neuroinflammation in the cerebellum by 35%.

Brain Derived Neurotropic Factor (BDNF) is key for maintenance of normal neuronal function and energy homeostasis and has been suggested to improve cognitive function including learning and memory. Iron is crucial for normal neuronal function.4 It has also been demonstrated that older patients with iron deficiency had reduced cognitive function (measuring MMSE scores – mini mental state examinations).5

A recent study by Westminster University revealed, the co-administration of HydroCurc with low dose iron, over a 42-day period, significantly increased serum BDNF (brain derived neurotrophic factor) and iron levels, versus iron on its own.6

The importance of cognitive health and wellness is increasing for consumers both young and old, who are looking to a prevention rather than cure approach. Manufacturers and brand companies can easily formulate their products with HydroCurc to ensure consumers are able to reap the many therapeutic benefits that curcumin has to offer. Pharmako’s HydroCurc delivers the highest dose of curcuminoids per mL of blood plasma on the market today. To learn more about HydroCurc visit:

Register to download "The world's most bioavailable curcumin in a single dose" infographic now.

1 Briskey, D., Sax, A., Mallard, A.R. et al. Increased bioavailability of curcumin using a novel dispersion technology system (LipiSperse®).

Eur J Nutr 58, 2087–2097 (2019).

2 Wignall A. et al., (2020) Mechanistic Insight into Pharmako’s Oral Curcumin Product: LipiSperse®

3 Muench G, Jabur L, Niedermayer G, (2021) “Quantification and Measurement of Natural Compounds: Curcumin”

4 Beard JL, Connor JR. “Iron status and neural functioning.” Annu. Rev. Nutr. 2003, 23, 41-58. DOI: 10.1146/annurev.nutr.23.020102.075739

5 Yavuz BB et al. “Iron deficiency can cause cognitive impairment in geriatric patients.” J Nutr Health Aging.

2012;16:220-224. DOI: 10.1007/s12603-011-0351-7

6 Lorinczova HT, Fitzsimons O, Mursaleen L, Renshaw D, Begum G, and Zariwala M.

“Co-Administration of Iron and a Bioavailable Curcumin Supplement Increases Serum BDNF Levels in Healthy Adults”

Antioxidants 2020, 9, 645; doi:10.3390/antiox9080645

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