Research demonstrates Lycoderm’s mechanisms of action

Published: 9-Aug-2021

The study further substantiated the ingredient’s bioavailability

Recent research indicates the blend of tomato and rosemary extracts in Lycored’s Lycoderm ingredient has a synergistic effect that may help balance skin cells’ response to environmental challenges.

Designed to promote wellness from within, Lycored’s ingestible skincare extract contains a combination of carotenoids and polyphenols including lycopene, phytoene, phytofluene, and carnosic acid.

Previous research has reportedly shown the ingredient can benefit overall skin condition as well as visibly boosting radiance and reducing the appearance of lines and wrinkles.1 Now, a study published in Molecules has provided further insight into its molecular mechanism, further validating the blend’s ability to support skin health at the cellular level.2

The pre-clinical tests demonstrated the phytonutrients in Lycoderm cooperate to inhibit inflammatory cytokines which lead to the degradation of skin collagen. Its patented combination of carotenoids and polyphenols was found to inhibit the secretion of the cytokines and balance oxidative stress far more effectively than either tomato extract or rosemary leaf extract alone.

The study further substantiated the ingredient’s bioavailability. A group of healthy subjects began taking Lycoderm in addition to their regular diet, with blood tests taken two and three weeks after beginning supplementation. Results showed the average plasma concentration of the major tomato carotenoids almost doubled.

As such, Lycored says, the study underlines the benefits of supplementation with tomato nutrients on top of a healthy diet, demonstrating mechanisms of action to support health and beauty across skin types and age groups.

Karin Hermoni, Head of Product and Science at Lycored, said: “When creating Lycoderm, we were aiming for the ultimate mix of carotenoids naturally present in the tomato alongside the polyphenols in natural rosemary leaf extract. This research shines a light on how these phytonutrients work together to nourish the body from the inside out, helping to maintain skin health and wellness to achieve an ‘inner glow.’”

Lycoderm is a plant-based, clean-label solution to be used in a range of dietary supplements and is GRAS for food and beverage use.


1. Tarshish, E., Hermoni, K. & Schwartz, S.R. 'Effect of oral supplement “Lycopene” on reducing the signs of skin ageing' Clinical Pharmacology and Biopharmaceutics (2020)

2. Calniquer, G. et al. 'Combined effects of carotenoids and polyphenols in balancing the response of skin cells to UV irradiation' Molecules (2021)

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