Pomegranate extract could slow progression of age-related frailty, study finds

Published: 28-Feb-2024

Pomegranate extract reverses loss of motor coordination and prevents oxidative stress in ageing mice, according to independent research study conducted at the University of Valencia

A recently published study shows that Euromed’s pomegranate extract Pomanox can promote healthy ageing in mice. 

The substance was found to prevent frailty, improve motor skills and reduce oxidative stress in the cerebellum, a segment of the brain responsible for coordination. 

Falling and subsequent bone fractures are one of the major health risks in elderly people. Therefore, the researchers of this model study looked at how to overcome the problem by addressing balance and stance, which are controlled by the cerebellum.

The cerebellum is also responsible for coordination of voluntary movements, motor learning and cognitive tasks. During the ageing process, most of these functions deteriorate, resulting in falls and accidents. 

In the study, Pomanox was able to maintain antioxidant levels in elderly mice after four months of supplementation. This effect was particularly evident in the cerebellum. 

Pomegranate extract supplementation improved the motor skills in terms of coordination and neuromuscular function

Moreover, the standardised pomegranate extract influenced gene expression related to the apoptosis pathway, suggesting support for healthy ageing.

Although no changes in grip strength and endurance were found, the results showed that pomegranate extract supplementation improved the motor skills in terms of coordination and neuromuscular function, and helped prevent age-related weight loss. 

Thus, the researchers believe that Pomanox may provide practical nutritional support for common health problems, such as frailty, in later life.

Pomegranate’s health benefits come from punicalagins, which are among nature’s strongest antioxidants. Pomanox contains up to 30% punicalagins and is a well-researched botanical ingredient from Euromed’s Mediterranean fruit and vegetable extracts range.

It’s obtained via a quality-controlled, transparent and sustainable local supply chain, and gently processed with an eco-friendly, proprietary technology.

Andrea Zangara, Head of Scientific Communication and Medical Affairs at Euromed, says: “Pomanox® is already well known to provide benefits for cardiovascular and metabolic health, satiety, sports performance, mood, skin and cognitive health. The novelty of this work focuses on the fact that the pomegranate extract could be used to help prevent deterioration associated with normal ageing.”


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