A new human clinical study featuring Witholytin, a high-quality, proprietary ashwagandha extract, evaluated the positives effects on fatigue and stress.
Researchers evaluated the safety of this ashwagandha and its impact to perceived fatigue and stress in 111 healthy men and women, aged 40-75 years old, experiencing low energy and moderate-to-high perceived stress over a 12-week period. The study used a dosage of 200mg ashwagandha twice a day.
The results indicated a significant 45.81% decrease in the total score of the Chalder Fatigue Scale (CFS) and a 38.59% reduction in stress levels, as measured by the Perceived Stress Scale, for participants taking ashwagandha compared to their baseline scores after 12 weeks.
Additional results saw an 11.41% increase (improvement) on physical score in the Patient-Reported Outcome Measurement Information System-29 (PROMIS-29), a 26.30% reduction on mental score (improvement) in PROMIS-29, and a 9.1% increase in Heart Rate Variability (HRV) compared to a 18.8% reduction in the placebo group.
The conclusion of this study suggests ashwagandha’s potential to support an adaptogenic approach while combating fatigue, restoring vitality, and promoting homeostasis and balance.
Researchers involved in this investigation claimed that this ashwagandha demonstrated significant energy bolstering effects in overweight middle-to-older age adults who are experiencing high stress and fatigue.
A sub-analysis was conducted to investigate hormone biomarkers in both the male and female participants. Among the men who consumed ashwagandha, a significant 12.87% rise in blood concentrations of free testosterone (p = 0.048) and luteinising hormone (p = 0.002) was observed compared to the placebo group.
Considering these outcomes, it is important to further explore the demographic groups that could potentially benefit from ashwagandha supplementation, given that its stress-reducing effects may vary based on factors such as age, gender, BMI status, and other variables.
“We are excited to have this new publication join the evidence in support of Witholytin and our mounting body of evidence for ashwagandha extract standardisation to USP methodology,” explains Verdure Sciences’ Executive Vice President, Sonya Cropper. Cropper continued, “tremendous interest continues to build for ashwagandha, adaptogens, fatigue, energy, and mental vitality.”
Witholytin is produced by Verdure Sciences and distributed across Europe by LEHVOSS Nutrition, a division of LEHVOSS Group
