Joint discomfort affects millions worldwide, limiting mobility, flexibility, and quality of life. Consumers today are looking for natural, science-backed alternatives that work quickly and safely. That’s where Axtragyl®, a standardized extract of Astragalus membranaceus, makes the difference.
Results you can trust
A randomized, double-blind, placebo-controlled clinical trial¹ with 90 healthy adults experiencing knee discomfort tested 480 mg/day of Axtragyl®. The outcomes were remarkable:
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Fast action: significant reduction in knee discomfort after just 5 days.
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Powerful relief: by day 28, 82% less discomfort compared to baseline.
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High response rate: 89% of participants achieved at least a 30% reduction in knee discomfort.
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Better mobility: knee range of motion doubled from baseline, with measurable improvements starting as early as day 5.
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Enhanced performance: in the Stair Climb Test, Axtragyl® users improved their time by 2.4 seconds versus baseline, a 19% boost in functional capacity compared to placebo.
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Excellent safety: all safety parameters remained within normal values.
Even more compelling, a laboratory study² from Sapienza University of Rome showed that Axtragyl® can significantly modulate inflammatory markers and enzymes responsible for cartilage breakdown. Specifically, the extract reduced the expression and release of pro-inflammatory cytokines such as IL-6, IL-1β, and IL-8, while downregulating key matrix-degrading enzymes including MMP-3, MMP-13, and ADAMTS-5. These combined effects protected human chondrocytes, the cells responsible for maintaining healthy cartilage, by restoring balance in the joint environment and helping to prevent structural damage over time.
Why it matters
Unlike traditional solutions that may take weeks or months to show results, Axtragyl® delivers rapid improvements in joint comfort, flexibility, and mobility, while supporting long-term protection against cartilage degradation.
Backed by science and inspired by nature, Axtragyl® helps people of all ages move with confidence while setting a new standard in natural joint support.
References
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Lippi L, Turco A, Rudrappa GH, Moalli S, De Sire A, Invernizzi M. Astragalus membranaceus extract reduces functional knee joint pain: a randomized, double-blinded, placebo-controlled trial. Frontiers in Pain Research. 2025; 6:1595957.
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Mariano A, Russo R, Scotto d’Abusco A, Superti F. Astragalus membranaceus extract attenuates inflammatory cytokines and matrix-degrading enzymes in human chondrocytes: a novel nutraceutical strategy for joint health. Current Issues in Molecular Biology (CIMB). 2025; 47:731.