The antioxidant, anti-inflammatory, immunomodulating, anti-thrombotic, antiviral and anticancer effects of vitamin C along with its respiratory protective effects has generated a great interest in vitamin C as an attractive dietary/nutraceutical supplement for the management of COVID-19. In fact, low levels of plasma vitamin C have been correlated with the severity of illness among Pneumonia, Sepsis and COVID-19 patients. But, the salt like nature, high water solubility, rapid elimination and its inability to overcome the tight intestinal control have led to its poor oral bioavailability.
FENUMAT™- a platform delivery technology developed and patented by the in-house R&D efforts of Akay, has already received a great attention and appreciation as a GREEN technology for oral delivery. It is the first 100% natural, clean label & food-grade technology (water-based green approach) in the oral delivery of phytonutrients with enhanced bioavailability. Being a biopolymer based technology (fenugreek- soluble dietary fibre (galactomannans)- based) it is named as FENUMAT™. It can be considered as a Natural Self-emulsifying Reversible Hydrogel based delivery system (N-SERH) for the sustained-intestinal delivery of lipophilic phytonutrients with enhanced absorption. The unique chemical structure and high molecular weight makes FENUMAT™ an ideal carrier for drug delivery!
Some successful formulations using FENUMAT™ technology are: CurQfen®, BosQfen®, Capsifen®, Asafin®, and a Co-delivery form of “Curcuminoids and Boswellic acids” for joint health.
As mentioned earlier, vitamin is a highly water soluble crystalline solid form. It dissolves instantly and undergo rapid systemic elimination, though the absorption is good. So, people have tried various controlled-release forms. But, unfortunately controlled-release forms have not enhanced the plasma bioavailability of vitamin C. Recently, liposomal formulations have emerged. But again, with no significant enhancement even at 4 to 36 g dose. Here we introduced a modified version of FENUMAT™ technology as Hybrid-FENUMAT™, to overcome the inherent issues of liposomal forms which leads to poor performance of liposomes when delivered in vivo. Hybrid-FENUMAT™ provided high loading, enhanced stability, permeability and bioavailability (7-fold) from the liposomal structures. The formulation is well characterized with most-modern-state-of-the-art sophisticated instruments used in Nanotechnology. Manuscript is under revision by a high impact scientific journal.
Contact us to know how we tailor-make formulations using our patented FENUMAT™ for various kinds of Nutrients, Innovative & Disruptive as it is 100% Natural.
FENUMAT™ Opens up a new route to next generation Nutraceuticals. Natural, Organic, Clean Label and Bioavailable
