New study shows significant effect of Quatrefolic in lowering Homocysteine Serum Levels

High blood levels of homocysteine signal a breakdown in this process, resulting in far-reaching biochemical and life consequences

A recently new published study (Mazza et al., Nutraceutical approaches to homocysteine lowering in hypertensive subjects at low cardiovascular risk: a multicenter, randomized clinical trial. J Biol Regul Homeost Agents. 2016) has investigated the efficacy of Quatrefolic (400 mcg of Quatrefolic® plus B6, and B12 BID) in lowering homocysteine serum levels (HCys) versus a conventional vitamin supplementation (folic acid + vitamin B) in hypertensive subjects at low cardiovascular risk.

Homocysteine is a metabolite of methionine metabolism in the one carbon metabolism, often referred to as the methylation cycle, and exists at a critical biochemical intersection - between S-adenosylmethionine, the indispensable ubiquitous methyl donor, and 5-MTHF and vitamins B12. Homocysteinemia may be caused by several nutritional deficiencies other than B12, including vitamin B6 and folate deficiencies and decreasing plasma total homocysteine by providing nutritional cofactors for its metabolism has been shown to reduce the risk of cardiovascular events.

High blood levels of homocysteine signal a breakdown in this vital process, resulting in far-reaching biochemical and life consequences. As a matter of fact, the link between homocysteine and cardiovascular disease is well established especially in elderly[3]. High Hcys concentrations inhibit the proliferation of vascular endothelial cells, decrease the antioxidant activity of superoxide dismutase on endothelial cell surfaces, and impair endothelial function. They are also implicated in the pathophysiology of essential hypertension. Hyperhomocysteinemia exerts its deleterious vascular effects through production of free-reactive oxygen species that cause oxidative stress[7] as a result of antioxidant/prooxidant imbalance and probably also by inhibition of intracellular glutathione peroxidase.


The study carried out by Dr. Mazza enrolled one-hundred and four patients (mean age 62.8┬▒14.5 years, 63.5% males), 52 for each treatment group and recruited patients with stage 1 essential hypertension and hyper-homocysteinemia (HCys ≥15 μmol/L), without a history of cardiovascular and cerebrovascular disease.

The treatment had a significant effect and the ideal HCys level was reached in 55.8% of cases in the Quatrefolic® group, and it was significantly higher than in controls.


No side effects were observed in either treatment group. Homocysteinemia is widely accepted as an independent risk factor for coronary, cerebral and peripheral vascular diseases.

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