As a pioneer of innovation-driven ingredients, ROELMI HPC explores the world with genuine curiosity, selecting the best botanical sources to develop effective ingredients for people’s health and beauty.
Inspired by nature and driven by science, the SelectSIEVE® line by ROELMI HPC aims to preserve bioactive phytochemical compounds while delivering high-quality nutraceutical ingredients backed by scientific evidence.
ROELMI HPC’s innovation laboratories have developed a new botanical complex dedicated to the management of obesity and metabolic syndrome. SelectSIEVE® HopE is a technologically advanced nutraceutical ingredient derived from the cones of Humulus lupulus. Its mechanism of action includes the boost of GLP-1 secretion, the upregulation of PPAR-α and PPAR-γ activity, and the modulation of key enteric hormones involved in metabolic balance. Obtained through supercritical CO₂ extraction, it delivers a standardised hop phytocomplex in a stable powder form rich in α- and β-acids, iso-α-acids, β-caryophyllene and several other valuable bioactives.
The efficacy of SelectSIEVE® HopE has been investigated in a randomised, placebo-controlled clinical study involving 66 overweight and mildly obese subjects with metabolic syndrome according to IDF criteria. The study reported improvements in waist circumference, body weight and BMI, together with improvements in key markers of glucose metabolism, including fasting insulin, HbA1c and HOMA-IR, as well as the Visceral Adiposity Index (VAI).
Through a multifactorial approach and the enhancement of metabolic function, it contributes to improving insulin sensitivity and weight loss, supporting overweight and type II diabetes.
SelectSIEVE® HopE is the ideal ingredient for the development of innovative metabolic health solutions acting along the gut–liver axis.
Further information: https://www.roelmihpc.com/portfolio/selectsieve-hope/
