Isomaltulose ingredient proves efficacious in regulating metabolism, study shows

Published: 4-Jun-2024

Palanitose was proven to regulate GLP-1 levels in overweight and obese participants with and without Type 2 diabetes, proving its capability to assist in promoting a healthy metabolism

A novel study commissioned by Beneo has demonstrated that intake of its proprietary smart carbohydrate Palatinose stimulates the release of beneficial gut hormones including GLP-1 in overweight adults — even if its consumption is followed by a meal. 

The trial, lead by Prof. Andreas Pfeiffer (Zhang et al.[i]), demonstrates that Palatinose stimulates the release of beneficial gut hormones including GLP-1 in overweight adults.

The findings indicate that Palatinose (isomaltulose) has a beneficial effect on metabolic parameters that assist in maintaining a healthy body weight, blood glucose control and cardiovascular health.


GLP-1's impact on metabolic health

GLP-1 has been previously implicated in the process metabolic control, influencing the reduction of appetite and thereby weight gain. The benefits of the gut hormone are widely studied and drugs mimicking the effects of GLP-1 are used in the treatment of Type 2 diabetes. 

Some of these treatments have recently gained a huge amount of interest for reducing obesity and are being positioned as ‘weight loss’ drugs.

The study

The study was designed to explore the effect of Palatinose compared to sucrose, on the release of gut hormones. 

Using a double-blind, randomised, placebo-controlled, cross-over design, the study was undertaken with 30 overweight/obese volunteers, aged between 49 and 77.

Half of the participants also had Type 2 diabetes. The participants’ blood glucose, insulin and incretins — including GLP-1 — were monitored over a nine-hour period.
The first three hours of measurement showed the volunteers’ metabolic response to breakfast, with no intervention. At the three-hour marker, a drink containing 50g isomaltulose or 50g sucrose was consumed, followed by lunch one hour later. 


Palatinose promotes the release of gut hormones, even when consumed one hour before a complex meal

The results

The study showed that those who had consumed the isomaltulose, even as a pre-lunch drink, produced significantly higher GLP-1 levels than those who had ingested sucrose. 

As demonstrated for the first time, the stronger release of gut hormones with Palatinose is not masked by a subsequent meal. Thus, it can be concluded that Palatinose promotes the release of gut hormones (including GLP-1) even when consumed one hour before a complex meal.
GLP-1 has a beneficial impact on metabolism, including the reduction of appetite and weight gain, whilst also improving blood glucose control. 

The study findings again show that Palatinose influences factors which contribute to a better metabolic state and therefore provides benefits beyond slow released and sustained energy.
Head of Nutrition Science at BENEO Stephan Theis said: “Research on metabolism regulating gut hormones is an exciting topic for clinical nutrition and meal replacement applications. This study’s focus on older, overweight and obese participants, with or without diabetes mellitus, makes it highly relevant for a large part of the global population. The findings add to the already existing scientific evidence on isomaltulose’s ability to support metabolic health in daily life situations, including a higher secretion of the beneficial gut hormone GLP-1 in the general population.”

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