Fortifying ageing liver function with a citrus flavonoid blend

Published: 29-Feb-2024

Eriomin enhanced the activity of hepatic antioxidant enzymes, including glutathione peroxidase (GPx), glutathione reductase (GR), and catalytic glutamate-cysteine ligase

Ingredients by Nature is pleased to announce the publication of its experimental research in the BioFactors Journal investigating Eriomin, a multi-patented citrus flavonoid blend, and its potential to support liver function and the aging liver. 

As we age, the body’s natural ability to counteract reactive molecules, including free radicals and other oxygen-containing molecules, diminishes significantly. 

This decline contributes to higher levels of oxidative stress, associated with systemic inflammation and a spectrum of chronic illnesses and age-related problems. 

Consuming antioxidant-rich substances through diet, supplements, or nutraceuticals can assist the body in managing the oxidative stress commonly linked with aging. 

“Previous studies have demonstrated that citrus flavonoids possess protective capabilities against oxidative stress, effectively supporting a healthy inflammatory response,” said Dr Thais Cesar, lead researcher and scientific advisor to Ingredients by Nature. 

“Eriomin has exhibited antioxidant and anti-inflammatory activity in both young and adult animals and humans. Inflammation linked to the aging process (inflammaging) is damaging and a major risk factor and marker for serious age-related conditions. Longevity is an exciting and rapidly growing area for nutraceuticals, and as such, we wanted to assess Eriomin’s effectiveness in the aging process.”


The study 

This published study explored hepatic redox regulation in elderly rats after four weeks of Eriomin administration. The study evaluated the impact of Eriomin supplementation on the liver, a highly susceptible organ to the oxidative processes of aging. 

Biochemical and molecular tests were conducted to assess Eriomin’s potential in regulating hepatic redox activity and hepatic protein persulfidation levels.

The study results revealed that Eriomin enhanced the activity of hepatic antioxidant enzymes, including glutathione peroxidase (GPx), glutathione reductase (GR), and catalytic glutamate-cysteine ligase.

Furthermore, Eriomin treatment increased the activity of the nuclear transcription factor Nrf2, a key player in cellular defence against oxidative stress and the maintenance of redox homeostasis. 

These findings highlighted Eriomin’s ability to modulate hepatic redox regulators Nrf2 and Trx1 (thioredoxin 1), alleviate oxidative stress, and reduce persulfidation levels, suggesting a substantial and beneficial antioxidant potential of lemon flavanones in aging livers.

“This study provides new insights into the positive impact of Eriomin on the hepatic redox environment, further positioning Eriomin as a promising approach for potent antioxidant and inflammatory support,” said Rob Brewster, president at Ingredients by Nature. 

“Eriomin is already patented for boosting GLP-1 levels (Glucagon-Like Peptide-1). GLP is known for its role in the body’s natural glucose absorption and feeling of satiety, and it is the key mechanism of action behind several blockbuster pharmaceuticals. We are thrilled with the outcomes of this study and plan to conduct further investigation into Eriomin’s impact on the aging body.”

Eriomin is a high-potency proprietary lemon flavonoid blend primarily composed of Eriocitrin, a flavonoid naturally found in lemons and oranges. 

The ingredient is also clinically validated to aid in maintaining healthy blood glucose levels, supporting normal insulin sensitivity, boosting glucagon-like peptide-1 (GLP-1), and supporting a healthy prediabetic microbiota.

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