Gencor finds PEA extract is safe and effective for knee osteoarthritis

PEA is structurally related to an endogenous cannabinoid transmitter that is associated with regulating pain

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A new study has shown that Levagen, Gencor’s Palmitoylethanolamide (PEA) extract, is safe and effective for knee osteoarthritis. The product helps in the capacity of an anti-inflammatory, analgesic, and tissue-protective nutrient.

PEA is produced in the body as a biological response and as a repair mechanism for inflammation. It is a simple fatty acid amide that is structurally related to the endogenous cannabinoid transmitter, anandamide (AEA). AEA is associated with regulating pain, and the more AEA in the bloodstream, the less discomfort a person may feel. PEA has numerous clinical studies demonstrating it is an effective and safe anti-inflammatory, analgesic, and tissue-protective nutrient.

The recently published study aimed to examine the safety, tolerability and efficacy of palmitoylethanolamide (PEA) when dosed at 300 mg and 600 mg per day on symptoms of knee osteoarthritis.

“Osteoarthritis is one of the most common joint related concerns caused by the breakdown of articular cartilage and remodelling of joint tissues driven by inflammatory mediators,” said R.V. Venkatesh, Managing Director at Gencor. “The results of this study demonstrated the powerful effects of Levagen and its ability to not only reduce WOMAC pain scores, but its ability to reduce anxiety levels, according to the Depression Anxiety Stress Scales (DASS).”

The eight-week, double-blind randomised placebo-controlled study also concluded that Levagen may be a novel treatment for attenuating pain and reducing other associated symptoms of knee osteoarthritis at both 300 mg and 600 mg per day.

“PEA is unique due to its several fast-acting therapeutic effects,” said Chase Shryoc, VP of Sales and Business Development. “The study recipients reported a gradual reduction of WOMAC pain scores in just one week with further significant reductions at week four and eight. In addition to joint health, Levagen can also aid in restful sleep and recovery.”

This is by no means the only clinical study being done on Gencor’s Levagen. Further results are expected to be released later this year. Gencor is also putting additional research into Levagen+, its cold-water dispersible powder, specifically designed to increase the bioavailability of PEA.

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