Vitamin K2 MK-7 may be beneficial for heart health, study finds

Published: 2-Feb-2024

Novel research has highlighted the potential of vitamin K2 MK-7 as a heart health supplement

Balchem, a global manufacturer of speciality nutritional ingredients for health and nutrition, have recently announced the latest findings of the aortic value decalcification trial (AVADEC). 

The latest findings from a peer-reviewed paper – published in the Journal of the American College of Cardiology (JACC) – have revealed the potentially positive effects of vitamin K2 MK-7 and vitamin D intake on coronary artery calcification (CAC) progression specifically.
The AVADEC trial investigated the impact of daily vitamin K2 and D supplementation on CAC progression – which is strongly associated with a higher risk of heart disease and negative cardiovascular events. 

No significant effect was observed on the CAC score in the total group. 

However, the peer-reviewed research in JACC did find that two years all-trans vitamin K2 MK-7 (720 µg/d K2VITAL DELTA vitamin K2 MK-7) and vitamin D (25 µg/d) intervention in a subgroup analysis of participants at high-risk of CAC (CAC score ≥ 400 AU) with no prior ischemic heart disease significantly slowed down the progression of the CAC score. 

Statin users also displayed a significant slowdown in the progression of the CAC score following vitamin K2 and D intervention. 

A further noteworthy observation was that the number of adverse “events” in patients – that is acute myocardial infarction, coronary revascularisation and all-cause death – was lower in the group receiving vitamin K2 MK-7 and D supplementation compared to placebo.
Principal investigator of the study, Professor Axel Diederichsen, Odense University Hospital in Denmark, comments on the findings: “Scientific observations reveal that vitamin K2 and D supplementation play an important role in heart health – but there is limited research that delves deeper into the mechanism of action behind this benefit. Our research set out to fill this gap in knowledge, with discoveries from the subgroup analyses offering promising insights into the role of both vitamins in calcification in specific populations.”

Statin users (also) displayed a significant slowdown in the progression of the CAC score following vitamin K2 and D intervention

In addition to its possible role in CAC progression, the potential of vitamin K2 MK-7 to boost arterial health is also being investigated.

One recent study demonstrated that 24 weeks 375 µg/d K2 MK-7 intake provided a beneficial impact on lowering the rate of arterial stiffness progression in chronic hemodialysis patients with diabetes.

Another trial highlighted the effect of 360 µg/d K2 MK-7 on arterial elasticity in vitamin K-deficient kidney transplant recipients after 12 weeks; concluding that K2 intervention supports healthy progression of arterial stiffness.


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