Zeus Hygia has introduced its new ingredient, Metaberine, a bioavailability-enhanced berberine ingredient, that offers a "powerful alternative to conventional berberine and expensive GLP-1 therapies."
Metaberine is produced using the company's proprietary BioSOLVE technology, a 100% aqueous green process and, according to Zeus Hygia, delivers clinically validated metabolic health benefits at a minimal daily dose of 200 mg.
The company also announced the results of a pharmacokinetic study comparing both 200 mg Metaberine and berberine extract powder.
In a randomised, double-blind, placebo-controlled, crossover trial, 36 participants were supplemented with 200 mg Metaberine for 14 days and were assessed for metabolic parameters.
The research demonstrated that the maximum concentration (C max ) of Metaberine was 37 times higher than that of berberine powder and the time to reach Cmax (T max ) for Metaberine was 30 minutes, compared to eight hours for berberine powder, per Zeus Hygia.
Additionally, Metaberine demonstrated nine times greater bioavailability.
The results also showed that the Metaberine group experienced a significant 23% increase in GLP-1 secretion, an eight per cent reduction in fasting blood glucose and a 14% decrease in post-prandial glucose spike. Additionally, a two per cent reduction in LDL cholesterol was observed.
Metaberine supports healthy metabolic function through several complementary pathways: it promotes gut microbiome balance and activates AMPK, which enhances glucose uptake by muscles, decreases hepatic glucose production and improves mitochondrial function.
Currently, the second Human Clinical study of Metaberine in 100 subjects at a 200 mg daily dose for eight weeks is underway and expected to be completed by the first half of 2026.
"Metaberine outperforms conventional berberine, as our studies demonstrate," said Dr Arunkanth Krishnakumar, co-founder and director of India and Florida-based Zeus Hygia.
"GLP-1 agonists have become prominent in the conversation about weight loss and blood sugar management, but these solutions often come with intense GI side effects and are cost-prohibitive for many."
As a natural, safe and clinically proven lowest-dose alternative, Metaberine can be a reliable and affordable metabolic health-support intervention.
"Metaberine is acknowledged as the most effective and thoroughly researched metabolic support available at the lowest daily dosage. Several supplement formulations with Metaberine are prepared to launch in the US market within the coming months."