Magtein's support for brain health bolstered by positive trial results

Published: 28-Jan-2026

The study builds on earlier research that demonstrated Magtein supports cognitive performance in older populations and suggests that the benefits may also extend to younger adults, along with additional outcomes related to cognitive function, sleep-related measures and physiological markers

A newly published study has demonstrated that supplementation with Magetein (magnesium L-threonate) can help improve cognitive performance in consumers with impaired sleep.

The randomised, double-blind, placebo-controlled clinical trial, published in Frontiers in Nutrition, found that 2 g daily supplementation with Magtein for six weeks was associated with improvements in cognitive performance and multiple related outcomes in 100 healthy adults (ages 18-45) with self-reported dissatisfied sleep.


Study results

Participants supplementing with Magtein demonstrated the following improvements:

  • Improved overall cognitive performance,
  • Greater improvements in working and episodic memory,
  • A 7.5-year reduction in estimated brain cognitive ageing,
  • Faster reaction times,
  • Reduced resting heart rate (HR) and increased heart rate variability (HRV),
  • Improvement in PROMIS sleep-related impairment.

The new results also build on and help reaffirm earlier clinical evidence in older adults.

In a trial published in 2015 using older adults with cognitive impairment, supplementation with a regimen containing magnesium L-threonate (L-TAMS) was associated with significant improvements in overall cognitive ability versus placebo.

These new results add clinical data to the growing body of evidence on Magtein, suggesting that younger adults as well as older populations can benefit from the ingredient. 

Dr Jennifer Gu, SVP of R&D at Magtein, said: "This study adds meaningful clinical data to the growing body of evidence on Magtein."

"While earlier studies have demonstrated Magtein supports cognitive performance in older populations, this research suggests benefits may also extend to younger adults—along with additional outcomes related to cognitive function, sleep-related measures and physiological markers such as heart rate variability, which is shown here for the first time."

Dr Gu added, “As additional ongoing and upcoming studies are completed, we look forward to further expanding the scientific understanding of Magtein and its role in formulations designed to support healthy brain cognitive ageing, stress resilience and sleep."

"As we look ahead, additional ongoing and upcoming studies will continue to expand our understanding of Magtein and its benefits. The growing body of evidence supports its use in formulations designed to support healthy brain cognitive ageing, stress resilience and sleep.”

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