With more than one-third of children reporting dietary supplement use, pediatric supplementation is already widespread (1). Yet the U.S. National Institutes of Health notes that many dietary supplements have not been tested in children, highlighting a significant evidence gap.
While food supplement ingredients are increasingly supported by laboratory research and clinical trials, evidence generated directly in children and reflecting real-world use remains limited. Activ’Inside is taking a science-driven approach to help bridge this gap. Rather than relying solely on laboratory data or extrapolating findings from adults, the company is testing its ingredients directly in children under real-world conditions.
Through two dedicated real-world studies, Activ’Inside is generating evidence for two science-backed active ingredients: Safr’Inside™, a patented, full-spectrum saffron extract standardized to 0.2% safranal by HPLC, and Memophenol™, a double-patented formula featuring a unique source of essential polyphenols.
The studies combine objective measures of efficacy and tolerability with feedback from children and parents, providing a more complete picture of how these ingredients perform in everyday life and helping translate scientific research into positive, measurable and consumer-relevant outcomes across attention, behaviour, sleep and cognitive performance.
Rather than relying solely on laboratory data or extrapolating findings from adults, the company is testing its ingredients directly in children under real-world conditions
Safr’Inside™ Kids: rapid and sustained improvements in attention, behaviour and sleep
Saffron (Crocus sativus L.) has gained increasing interest for its potential to support emotional and behavioural balance, attention and sleep quality. Safr’Inside™ is a patented saffron extract characterized by a high safranal content (≥0.2% by UHPLC). Its biological activity is supported by six demonstrated mechanisms of action (proprietary studies), including the modulation of serotonin pathways, inflammation, cortisol response and the gut microbiota.
Designed to explore the potential of Safr’Inside™ in children aged 7–12, this 42-day real-world study assessed its impact in gummy form on ADHD-related symptoms*, including attention, behaviour, calmness and sleep. These findings further expand the growing body of Safr’Inside™ research to a younger population.
Using the validated SNAP-IV** parent-reported validated questionnaire, first significant reductions were observed within just 14 days:
- -25.5% in inattention, with further improvement at day 42 (-46.9%)
- -21.2% in hyperactivity/impulsivity, with further improvement at day 42 (-37.6%)
- -25.8% in oppositional symptoms, with further improvement at day 42 (-39.4%)
Children’s feedback reinforced these findings:
- 2 in 3 reported better concentration
- 2 in 3 reported feeling calmer
- 7 in 10 reported better sleep
Parents also reported positive experiences: 7 in 10 were satisfied with the 15 mg/day child-adapted supplementation.
No side effects were reported.
Consumers increasingly seek solutions that can provide immediate support while delivering longer-term benefits with continued use
These results provide the first scientific evidence for Safr’Inside™ in children, further supporting its potential to promote calmness, concentration, behavioural balance and sleep, with benefits emerging rapidly and sustained over time.
Memophenol™ Kids: cognitive performance improves within two hours
Memophenol™ Kids builds on the strong scientific foundation of Memophenol™, a patented blend of grape and blueberry polyphenol extracts designed to combine synergistic neuroprotective, antioxidant and bioavailability benefits. The original ingredient has been validated through gold-standard clinical studies in both seniors and students, demonstrating measurable improvements in cognitive performance, including episodic and working memory.
Building on this established evidence in adults, Activ’Inside extends the science to a younger population with Memophenol™ Kids, demonstrating both rapid cognitive benefits after a single dose of 150mg and progressively greater improvements with continued supplementation.
What the real-world study showed:
- +10% cognitive performance after 2 hours
The acute effect observed after a single 150 mg powder stick-form dose is consistent with previous findings in students, where cognitive benefits were observed within 90 minutes versus placebo. With continued supplementation for up to 28 days, cognitive benefits increased over time, with improvements observed in both objective performance measures and parent-reported outcomes.
After 28days, Memophenol™ Kids objectively improves :
- +34% visual/auditory perception
- +37% working memory
- +40% contextual memory
- +47% recognition
This combination of rapid and sustained effects is particularly relevant as consumers increasingly seek solutions that can provide immediate support while delivering longer-term benefits with continued use.
Activ’Inside will be exhibiting at Booth H7-N16 at Vitafoods Asia 2026. Discover Safr’Inside™, Memophenol™ and other scientifically validated solutions, meet the Activ’Inside team, and discuss opportunities to develop the next generation of science-backed food supplements and wellness products.
Reference
1. https://abc30.com/post/more-third-children-teens-take-dietary-supplements-cdc-data-shows/19482153/
