Exploring the latest developments in digestive health

By Kevin Robinson | Published: 18-Sep-2023

Gut health has long been a subject of interest, but recent developments in the field have taken the conversation to new heights. In this interview, Dr Kevin Robinson (KSR) caught up with BENEO expert Anke Sentko (AS) who shed light on the evolving landscape of digestive wellness and its broader implications for our overall health

Our conversation delved into a range of topics, from prebiotic research to the exciting connection between gut health and mental well-being. I asked Anke about some of the latest developments in the field.

"It’s an area on the move," she remarked, no pun intended, noting that the focus has expanded beyond traditional concerns such as regularity.

“Today, researchers are exploring the intricate relationship between the gut and various aspects of metabolism, including the intriguing gut-brain axis.”

One of the key developments in digestive health research revolves around prebiotics (substances that promote the growth of beneficial gut bacteria).

One interesting study, for example, focused on whether enriching a final product with prebiotics such as inulin or oligofructose delivers the expected increase in Bifidobacteria after processing.

Researchers at the University of Reading used various food types enriched with prebiotics and compared them with pure inulin.1 

They measured the increase in Bifidobacteria in 96 participants and found that all the enriched food applications actually showed a significant increase in gut bacteria.

“This has significant implications for product developers and consumers, assuring them that prebiotics deliver the intended benefits even after processing."

Exploring the latest developments in digestive health

"This breakthrough underscores the integration of scientific research into practical dietary applications,” noted Anke, “especially as the increase was seen consistently across the various food applications.”

The link between gut health and mood
The conversation then turned to the connection between gut health and mental well-being. Anke delved into ground-breaking studies exploring the influence of gut microbiota on mood parameters.

In one study, researchers sought to determine if anxiety and depression could be positively affected by dietary interventions.

Participants with medium to low levels of these conditions were examined and the results were promising. Improvements derived from oligofructose supplementation were seen in mood parameters, along with an increase in Bifidobacteria and other beneficial bacteria.2

This suggests that a gut-mental health connection exists and that dietary interventions could play a role in alleviating mental health issues. “The focus was on providing evidence that prebiotics can positively influence our mental state,” Anke added.

Additionally, in collaboration with academic establishments such as The Max Planck Institute, research was done to understand whether prebiotics such as inulin could impact reward-related food decision-making processes.3

The study found that participants receiving inulin showed decreased brain activation when presented with high-caloric stimuli, indicating a reduced desire for such foods.

This suggests that prebiotics could help people to make healthier food choices, which is significant for weight management. I asked Anke whether a positive mood boost could be associated with making healthier choices and, although possible, she noted that it wasn’t a result parameter that was studied during the research.

What she did acknowledge, though, was that these trials represent a new level of gut health research: “Randomised and controlled trials are providing both credible results and proof of concept." 

"This advancement extends our understanding and shows that the gut-brain axis is not just theoretical; it’s actively influencing our choices."

"With more consumers interested in making positive changes and insurers supporting prevention, there’s a positive trend towards incorporating nutrition into mainstream medicine.”

KSR: Apart from digestive wellness, are there any other key drivers linked to the gut health trend?
AS: Certainly, digestive health is closely tied to overall well-being and many other factors contribute to this trend. One significant aspect is the growing interest in personalised nutrition.

People are recognising that there’s no one-size-fits-all approach when it comes to diet and wellness. Digestive health plays a crucial role in how our bodies respond to different foods and tailoring diets to individual needs can optimise overall health.

Exploring the latest developments in digestive health

KSR: So, are we seeing a shift in dietary patterns because of this awareness?
AS: Yes, definitely. As more research highlights the connection between gut health and various other outcomes, people are becoming more conscious of what they eat.

There's a greater focus on incorporating fibre-rich foods, probiotics and prebiotics into diets. Additionally, functional foods and supplements that support gut health are gaining popularity. This shift indicates a move towards proactive and preventive approaches to health.

KSR: Considering the ongoing studies and what we’ve already discussed, how far has the science of digestive health come since the 1980s when the first observations were made regarding beneficial Bifidobacteria being stimulated by fructo-oligosaccharides?
AS: It’s come a long way since then. The initial observations laid the foundations for what we know about the relationship between certain fibres and gut bacteria.

Numerous studies have now expanded our knowledge, explored different prebiotics, their effects on various bacteria and how these interactions influence our health. We currently have a more comprehensive understanding of how specific prebiotics impact different aspects of our well-being.

KSR: And looking ahead, what opportunities do you foresee for prebiotic research in the future?
AS: The future of prebiotic research holds immense potential. As we continue to uncover the intricate connections between the gut and overall health, there are opportunities to delve deeper into the mechanisms behind these interactions.

We can explore the impact of different prebiotics on specific health conditions, refine personalised dietary recommendations and even consider novel applications such as therapeutic diets for diseases.

Blurring the food–pharma lines
Wishing to expand on that notion, I ask Anke whether she thinks the concept of using prebiotics in therapeutic diets for the treatment of diseases — along with medical treatment and supervision — will become an everyday occurrence?

She acknowledged that for such integration to occur, robust scientific evidence is essential and emphasised that convincing medical professionals requires solid research that demonstrates the tangible impact of diet on health outcomes.

“The medical profession is gradually becoming more receptive to the concept of incorporating dietary interventions into treatment plans. With robust research showing the influence of gut health on various conditions, there's increasing recognition that diet can play a complementary role in medical treatment."

"However, it's a process that requires time for evidence to accumulate and for medical professionals to integrate these findings into their practice.”

Exploring the latest developments in digestive health

“The timeline for the widespread adoption of prebiotics in therapeutic diets depends on several factors. As more research is conducted and evidence accumulates, medical professionals will likely incorporate this approach into their practice."

"The pace of integration will also depend on educational initiatives and public awareness campaigns. With time, as people become more informed about the benefits of prebiotics and as the medical community gains confidence in their use, we can expect to see the concept become a more routine part of disease management strategies,” she said.

“This highlights the growing consumer interest in proactive health measures that encourage collaborations between medical professionals, nutritionists and dietitians.”

Too much prevention?
Drawing the conversation to a close, I suggest that variation in our digestive system is natural and often serves as a holistic indicator of our overall well-being.

Although we're making great strides in understanding and managing digestive health, I posit that it’s important to maintain a balance and not overdo it. Our digestive system’s natural variability can provide useful information about our health. Is there a risk of over-regulating the digestive system?

Anke thinks not! “Can prevention efforts be taken too far? I don’t believe so. Prevention aims to help individuals to avoid negative outcomes … but it’s always important to strike a balance and consider the whole approach."

"Our bodies are complex systems and a combination of factors, including diet, exercise and more all contribute to our well-being. Preventive measures are about making informed choices to support long-term health.”

In summary, and in the quest for holistic well-being, these recent developments in digestive health research paint a promising picture. From the influence of prebiotics on gut microbiota to their potential role in mood management, the intersection of science and diet holds the promise of enhancing our overall health and quality of life.

As we move forward, these findings pave the way for a new era of health-focused collaboration between medical practitioners, researchers and individuals seeking to optimise their well-being.


  1. P.P.J. Jackson, et al., “Effects of Food Matrix on the Prebiotic Efficacy of Inulin-Type Fructans: A Randomized Trial,” Beneficial Microbes (2023): DOI:10.1163/18762891-20220120.
  2. P.P.J. Jackson, et al., “Inulin-Type Fructans and 2’Fucosyllactose Alter Both Microbial Composition and Appear to Alleviate Stress-Induced Mood State in a Working Population Compared to Placebo (Maltodextrin): The EFFICAD Trial, A Randomized Controlled Trial,” Am. J. Clin. Nutr. (2023): DOI:10.1016/j.ajcnut.2023.08.016. 
  3. www.medrxiv.org/content/10.1101/2023.05.30.23290707v1.

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